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Addiction a brain disorder, not just bad behavior

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WASHINGTON (AP) — Addiction isn’t just about willpower. It’s a

chronic brain disease, says a new definition aimed at helping

families and their doctors better understand the challenges of

treating it.

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“Addiction is about a lot more than people behaving badly,” says

Dr. Michael M. Miller of the American Society for Addiction

Medicine.

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That’s true whether it involves drugs and alcohol or gambling and

compulsive eating, the doctors group said Monday. And like other

chronic conditions such as heart disease or diabetes, treating

addiction and preventing relapse is a long-term endeavor, the

specialists concluded.

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Addiction generally is described by its behavioral symptoms – the

highs, the cravings, and the things people will do to achieve one

and avoid the other. The new definition doesn’t disagree with the

standard guide for diagnosis based on those symptoms.

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But two decades of neuroscience have uncovered how addiction

hijacks different parts of the brain, to explain what prompts those

behaviors and why they can be so hard to overcome. The society’s

policy statement, published on its website, isn’t a new direction

as much as part of an effort to translate those findings to primary

care doctors and the general public.

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“The behavioral problem is a result of brain dysfunction,” agrees

Dr. Nora Volkow, director of the National Institute on Drug

Abuse.

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She welcomed the statement as a way to help her own agency’s work

to spur more primary care physicians to screen their patients for

signs of addiction. NIDA estimates that 23 million Americans need

treatment for substance abuse but only about 2 million get that

help. Trying to add compassion to the brain findings, NIDA even has

made readings from Eugene O’Neill’s “Long Day’s Journey into Night”

a part of meetings where primary care doctors learn about

addiction.

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Then there’s the frustration of relapses, which doctors and

families alike need to know are common for a chronic disease,

Volkow says.

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“You have family members that say, `OK, you’ve been to a detox

program, how come you’re taking drugs?'” she says. “The pathology

in the brain persists for years after you’ve stopped taking the

drug.”

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Just what does happen in the brain? It’s a complex interplay of

emotional, cognitive and behavioral networks.

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Genetics plays a role, meaning some people are more vulnerable to

an addiction if they, say, experiment with drugs as a teenager or

wind up on potent prescription painkillers after an

injury.

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Age does, too. The frontal cortex helps put the brakes on unhealthy

behaviors, Volkow explains. It’s where the brain’s reasoning side

connects to emotion-related areas. It’s among the last neural

regions to mature, one reason that it’s harder for a teenager to

withstand peer pressure to experiment with drugs.

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Even if you’re not biologically vulnerable to begin with, perhaps

you try alcohol or drugs to cope with a stressful or painful

environment, Volkow says. Whatever the reason, the brain’s reward

system can change as a chemical named dopamine conditions it to

rituals and routines that are linked to getting something you’ve

found pleasurable, whether it’s a pack of cigarettes or a few

drinks or even overeating. When someone’s truly addicted, that

warped system keeps them going back even after the brain gets so

used to the high that it’s no longer pleasurable.

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Make no mistake: Patients still must choose to fight back and treat

an addiction, stresses Miller, medical director of the Herrington

Recovery Center at Rogers Memorial Hospital in Oconomowoc,

Wis.

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But understanding some of the brain reactions at the root of the

problem will “hopefully reduce some of the shame about some of

these issues, hopefully reduce stigma,” he says.

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And while most of the neuroscience centers on drug and alcohol

addiction, the society notes that it’s possible to become addicted

to gambling, sex or food although there’s no good data on how often

that happens. It’s time for better study to find out, Miller

says.

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Meanwhile, Volkow says intriguing research is under way to use

those brain findings to develop better treatments – not just to

temporarily block an addict’s high but to strengthen the underlying

brain circuitry to fend off relapse.

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Topping Miller’s wish list: Learning why some people find recovery

easier and faster than others, and “what does brain healing look

like.”

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EDITOR’S NOTE – Lauran Neergaard covers health and medical issues

for The Associated Press.

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